pentobarbital will decrease the level or result of cannabidiol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Carefully. Take into account an increase in cannabidiol dosage (depending on scientific response and tolerability) when coadministered with a solid CYP3A4 inducer.
Contraindicated (1)pentobarbital will decrease the level or influence of cobimetinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Keep away from coadministration. Robust or reasonable CYP3A inducers could decrease cobimetinib systemic exposure by >eighty% and minimize its efficacy.
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pentobarbital will reduce the extent or influence of isradipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unidentified.
pentobarbital will lower the level or result of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. The efficacy of hormonal contraceptives can be lowered. Use of a nonhormonal contraceptive is suggested.
pentobarbital will decrease the level or result of rabeprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Importance Not known.
pentobarbital will lower the extent or result of amlodipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
pentobarbital will reduce the extent or outcome of etravirine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will minimize the level or effect of mestranol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep track of.
Sodium valproate and valproic acid surface to minimize barbiturate metabolism; hence, barbiturate blood levels ought to be monitored and acceptable dosage changes produced as indicated.
pentobarbital will lessen the extent or result of lumefantrine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with powerful CYP3A4 inducers can lead to lessened serum concentrations and loss of antimalarial efficacy
pentobarbital will decrease the extent or result of nicardipine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch.
Using barbiturates click here as sedatives while in the postoperative surgical period of time and as adjuncts to cancer chemotherapy is very well established